PharmacyCodes



Butenafinum [INN-Latin] en es it fr

Butenafinum [INN-Latin] Brand names, Butenafinum [INN-Latin] Analogs

Butenafinum [INN-Latin] Brand Names Mixture

  • No information avaliable

Butenafinum [INN-Latin] Chemical_Formula

C23H27N

Butenafinum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic2/butenafine.htm

Butenafinum [INN-Latin] fda sheet

Butenafinum_[INN-Latin] FDA

Butenafinum [INN-Latin] msds (material safety sheet)

Butenafinum [INN-Latin] Synthesis Reference

No information avaliable

Butenafinum [INN-Latin] Molecular Weight

317.467 g/mol

Butenafinum [INN-Latin] Melting Point

No information avaliable

Butenafinum [INN-Latin] H2O Solubility

Slightly soluble (HCl salt)

Butenafinum [INN-Latin] State

Solid

Butenafinum [INN-Latin] LogP

7.12

Butenafinum [INN-Latin] Dosage Forms

Cream (10 mg drug per gram of cream)

Butenafinum [INN-Latin] Indication

For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.

Butenafinum [INN-Latin] Pharmacology

Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.

Butenafinum [INN-Latin] Absorption

The total amount absorbed through the skin into the systemic circulation has not been quantified.

Butenafinum [INN-Latin] side effects and Toxicity

No information avaliable

Butenafinum [INN-Latin] Patient Information

Butenafinum [INN-Latin] Organisms Affected

Fungi